An experimental comparison of partitioning strategies in distributed graph processing

In this thesis, we study the problem of choosing among partitioning strategies in distributed graph processing systems. To this end, we evaluate and characterize both the performance and resource usage of different partitioning strategies under various popular distributed graph processing systems, applications, input graphs, and execution environments. Through our experiments, we found that no single partitioning strategy is the best fit for all situations, and that the choice of partitioning strategy has a significant effect on resource usage and application run-time. Our experiments demonstrate that the choice of partitioning strategy depends on (1) the degree distribution of input graph, (2) the type and duration of the application, and (3) the cluster size. Based on our results, we present rules of thumb to help users pick the best partitioning strategy for their particular use cases. We present results from each system, as well as from all partitioning strategies implemented in two common systems (PowerLyra and GraphX)

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat

The Toxoplasma gondii genome contains two aromatic amino acid hydroxylase genes, AAH1 and AAH2 encode proteins that produce L-DOPA, which can serve as a precursor of catecholamine neurotransmitters. It has been suggested that this pathway elevates host dopamine levels thus making infected rodents less fearful of their definitive Felidae hosts. However, L-DOPA is also a structural precursor of melanins, secondary quinones, and dityrosine protein crosslinks, which are produced by many species. For example, dityrosine crosslinks are abundant in the oocyst walls of Eimeria and T. gondii, although their structural role has not been demonstrated, Here, we investigated the biology of AAH knockout parasites in the sexual reproductive cycle within cats. We found that ablation of the AAH genes resulted in reduced infection in the cat, lower oocyst yields, and decreased rates of sporulation. Our findings suggest that the AAH genes play a predominant role during infection in the gut of the definitive feline host

Employees Plays an Important Role in the Food Chain Outlets

The workforce holds a crucial position in food chain establishments, as they directly interact with customers. The efficiency and responsiveness of these staff members are pivotal in meeting customer demands. Recognizing the significance of employees is essential for the success of these enterprises. The main objective of this study is to underscore the importance of employees and their impact on shaping the reputation of food outlets. This positive reputation, in turn, fosters customer loyalty and repeat business. To achieve this goal, it is the responsibility of management to maintain employee motivation, as motivated staff members are the cornerstone of organizational excellence

STRUCTURAL ELUCIDATION OF BIOACTIVE SECONDARY METABOLITES FROM ENDOPHYTIC FUNGUS

Objective: In this research for bioactive secondary metabolites from endophytic fungal isolate CPR5, which was later identified and characterized as Aspergillus niger sp.Methods: Eight bioactive compounds (1-8) were isolated and purified using a series of chromatographic techniques and identified by applying 13C and 1H nuclear magnetic resonance and mass (ESI-MS spectrometry).Results: All the compounds were tested for antimicrobial activity against a wide range of human and plant pathogenic bacteria as well as fungi. These microorganisms were, Xanthomonas oryzae, Escherichia coli, Streptococcus pneumonia, Bacillus subtilis, Staphylococcus hyicus, Bacillus sphaericus, Staphylococcus aureus, and Pseudomonas aeruginosa, Candida albicans, Sclerotium rolfsii, Sclerotinia, scleratiourum, and Phoma exigua minimum inhibitory concentration value have also been determine for these microorganism.Conclusion: In this study, a total 10 endophytic fungi were isolated from the Calotropis procera, show a great antibacterial activity against 24 human pathogenic bacteria

Optimization of process parameters for production of antimicrobial metabolites by an endophytic fungus Aspergillus sp. CPR5 isolated from Calotropis procera root.

Objective:To study the antimicrobial activity of crud ethylacetate  extract from endophytic fungus in Calotropis procera root.Methods:Endophytic fungus was screened for production of antimicrobial metablites.fermentation was carried out in 500 ml Erlenmeyer flask. Disc diffusion method was used to test antimicrobial activity of crude extract using chloramphenicol sulphate and Flucnazole as positive controleRessults: A total of fourteen Endophytic fungi were isolated (CPR1- CPR14). Among these fourteen isolates, CPR5 was found to show maximum antimicrobial activity, in compare to other isolates, against gram positive, gram negative bacteria and fungi. The antimicrobial activity was tested against Escherichia coli. Pseudomonas aeroginosa, Bacillus subtilis, Staphylococcus aureus, Ralstonia solanacearum, Xanthomonas oryzae, Penicillium chrysogenum, Candida albicans, Phoma exigua, Sclerotium rolfsii and Sclerotinia scleratiourum. Minimum inhibitory concentration (MIC) of crude extract against test microorganisms was determined. Fungus was identified as aspergillus sp. Prduction parameters (Temprature, pH, Carbon source, Nitrgen surce, Sdium Chlride concentration) were optimized.Conclusion:  Crud  extract produced by the isolated endophytic fungus could be an important source of broad spectrum antimicrobial metabolites. Keywords: Endophytic fungi, Antimicrobial metabolites, Process optimization, Calotropis procera, Inhibition zone

Knowledge and attitude towards emergency contraception in females of urban area of Lucknow, Uttar Pradesh, India

Background: Emergency contraception are birth control measures that, if taken after unprotected sexual intercourse, contraceptive failure, incorrect use of contraceptives or in cases of sexual assault may prevent pregnancy. The aim of the study was to assess the knowledge and attitude of female living in urban part of Lucknow district from September 2015 to August 2016.Methods: This was a descriptive, cross-sectional study conducted at RML Hospital, Lucknow from September 2015 to August 2016. A cross sectional study design was conducted and Participants were selected using simple random sampling method. Data was collected by using self-administered questionnaires. Data processing and analysis: The collected data was entered into a computer and analyzed using statistical package of social science version 20.0.Results: In this study it was found that, Out of 385 subjects 54% (209) new the correct time interval for EC to be effective and 91% (350) new that this is for prevention of unplanned pregnancy. Out of 385 subjects 77% (345) reported that they had heard the word EC from different sources, however 23% (90) reported that they never heard about that it means that still there is a scope of health awareness activities and health education to improve the knowledge of EC. Different attitudes of females towards emergency contraception some different pair of questions was asked. Out of 385 subjects 85% (329) were reported that they have positive attitudes in terms of benefits of EC to reduce the risk of unplanned pregnancy. A few number of subjects i.e. 12% (48) reported negative attitudes towards EC where as 3 % (8) did not respond. The more than half subjects i.e. 68% (260) reported that they use EC even if their partners disagreed with them where as 11% (41). Cultural belief was found as an barrier in having negative attitudes towards EC. The Religion, Occupation and educational status affect knowledge and attitudes towards EC.Conclusions: The results show that there is a scope of health awareness activities and health education to improve the knowledge and attitude towards EC

Disruption of Skin Stem Cell Homeostasis following Transplacental Arsenicosis; Alleviation by Combined Intake of Selenium and Curcumin

Of late, a consirable interest has grown in literature on early development of arsenicosis and untimely death in humans after exposure to iAs in drinking water in utero or during the childhood. The mechanism of this kind of intrauterine arsenic poisoning is not known; however it is often suggested to involve stem cells. We looked into this possibility by investigating in mice the influence of chronic in utero exposure to arsenical drinking water preliminarily on multipotent adult stem cell and progenitor cell counts at the beginning of neonatal age. We found that repeated intake of 42.5 or 85ppm iAs in drinking water by pregnant BALB/c mice substantially changed the counts of EpASCs, the progenitor cells, and the differentiated cells in epidermis of their zero day old neonates. EpASCs counts decreased considerably and the differentiated / apoptosed cell counts increased extensively whereas the counts of progenitor cell displayed a biphasic effect. The observed trend of response was dose-dependent and statistically significant. These observations signified a disruption in stem cell homeostasis. The disorder was in parallel with changes in expression of biomarkers of stem cell and progenitor (TA) cell besides changes in expression of pro-inflammatory and antioxidant molecules namely Nrf2, NFkB, TNF-α, and GSH. The biological monitoring of exposure to iAs and the ensuing transplacental toxicity was verifiable correspondingly by the increase in iAs burden in hair, kidney, skin, liver of nulliparous female mice and the onset of chromosomal aberrations in neonate bone marrow cells. The combined intake of selenite and curcumin in utero was found to prevent the disruption of homeostasis and associated biochemical changes to a great extent. The mechanism of prevention seemed possibly to involve (a) curcumin and Keap-1 interaction, (b) consequent escalated de novo GSH biosynthesis, and (c) the resultant toxicant disposition. These observations are important with respect to the development of vulnerability to arsenicosis and other morbidities later in life after repeated in utero or postnatal exposure to iAs in drinking water that may occur speculatively through impairment of adult stem cell dependent innate tissue repair mechanism